Faida Kučukalic had started residency in 1980 at the University Clinical Centre Sarajevo (UCCS). She had finished her residency in 1983 in Belgrade, Serbia. She is specialized in the field of cardio anesthesiology in referent cardio surgery centers in Western Europe. She is the Chief of Cardio anesthesiology and Intensive Care Unit at the Heart Centre UCCS. She received a recognition for special contribution for the development of cardio surgery- cardio anesthesiology from the Directory Board UCCS. She received her PhD titled: „ NT pro BNP as a marker left ventricle dysfunction“in 2013. She attended various congresses and published 60 papers.
Introduction: Congestive heart failure caused dominantly by coronary artery disease activates number of compensatory mechanism where secretion of natriuretic peptide takes a very important place. N-terminal pro brain natriuretic peptides is a established biomarker of ventricular dysfunction for diagnosis, screening, prognosis, monitoring and optimatisation of pharmacological management. Aims: High plasma levels of NTproBNP before cardiac procedure are associated with higher prognostic importance. Subjects and methods: We included 60 patients (43 man and 17 woman), undergoing coronary revascularisation (CABG), or replacement of aortic (mitral) valvule. All patients had left ventricular dysfunction with reduced ejection fraction (EF<40%). Plasma level of NTproBNP has been taken preoperatively, and postoperative 5 days after surgery. Results: Our results have shown that concentration of NTproBNP were 1322,2 pg/ml preoperatively, and in postoperative period 6067,9 pg/ml for all participants. The subgroup with severe dysfunction of the left ventricule (EF<30%) had value of NTproBNP 1560,47 pg/ml preoperatively while the subgroup with intermediate left ventricular dysfunction (EF 31-40%) had a value of 1194,00 pg/ml. In postoperative period in subgroup of participants with EF<30% NTproBNP level was 7219,23 pg/ml, compared with subgroup with EF 31-40% where this parameter valued 5461,00 pg/ml. Conclusions: Concentration of NTproBNP was correlated with left ventricular dysfunction. All participants had postoperative NTproBNP increase (p<1%). NTproBNP has a strong prognostic value and it will help us to identify patients who will need more intensive management after hospital discharge. Repeated biomarker measurement will become the strongest independent prognostic marker for rehospitalisation, adverse cardiovascular events and mortality in short and long-term period. Using NTproBNP as a biomarker-guide therapy we will try to act on the main goal of heart failure treatment, which include: prognosis, morbidity and motrtality.
Mohammad Murtaza Zaman was born on the 10th of April 1985 in a small town called Wah in the Rawalpindi district of Pakistan. After completing his schooling in Wah he went to Army Medical College Rawalpindi for his MBBS.He completed his degree in 2009 and went to the United Kingdom for further training. Subsequently he went through the UK foundation training,core medical training and passed his MRCP exams. Currently he is doing his masters degree in Cardiology from Kings College London as well as a fellowship in cardiology at Lister Hospital. His goal is to train as an interventional cardiologist and go back to Pakistan.
Atrial fibrillation is the most common sustained cardiac arrhythmia and results in significant mortality and morbidity predominantly due to ischemic stroke and heart failure. The prevalence is rising due to an increasing elderly population. Improved management strategies for ischemic heart disease and heart failure has resulted in a longer life expectancy and therefore increases the likelihood of developing AF secondary to these cardiac conditions. The American College of Cardiology, European College Society of Cardiology and NICE recommend a beta-blocker or a rate limiting calcium-channel blocker as first line treatment for controlling heart rate in patients who are haemodynamically stable. In clinical practice there seems to be debate among clinicians as to the superiority of one agent over the other. Searches were conducted in November 2015 on Embase (1974 to 2015 November), Ovid Medline (1946 to November Week 2, 2015) and the Cochrane Database. Four main facets were searched; ‘atrial fibrillation’, ‘beta-blockers’, ‘calcium-channel blockers’ and ‘rate control’. In total one hundred and nine (n=109) papers were returned. The duplicates were removed leaving ninety three (n=93) papers. All titles were reviewed and seventy-four were removed as they were irrelevant with regards to the question. Nineteen (n= 19) abstracts were pursued out of which fourteen were discarded for not meeting the eligibility criteria. Statistical analysis was carried out using the Review Manager software. The results showed that calcium-channel blockers were more effective than beta-blockers in controlling the heart rate at 20 minutes with a trend towards significance.